Small Extracellular Vesicles Secreted by Nigrostriatal Astrocytes Rescue Cell Death and Preserve Mitochondrial Function in Parkinson's Disease (Adv. Healthcare Mater. 20/2022)

Parkinson's Disease Like stars in a brain that are “wider than the sky”, astrocyte-derived extracellular vesicles illuminate intercellular space, landing on injured neurons to protect their mitochondria. This cover features work by Bianca Marchetti, Nunzio Iraci, and co-workers article 2201203. Mouse regions involved disease (PD, top): Striatum (blue), ventral midbrain (green). Region-specific astrocytes release (EVs, carriers of signaling molecules, center). EVs preserving mitochondrial functionality (bottom).